1. Inactivation of bacteria, viruses, fungi, yeast and protozoa:
Ozone disrupts the integrity of the bacterial cell envelope through oxidation of the phospholipids and lipoproteins. In fungi, ozone inhibits cell growth at certain stages. With viruses, the ozone damages the viral capsid and disrupts the reproductive cycle by disrupting the virus-to-cell contact with peroxidation. The weak enzyme coatings on cells which make them vulnerable to invasion by viruses make them susceptible to oxidation and elimination from the body, which then replaces them with healthy cells.
2. Enhancement of circulation:
In circulatory disease, a clumping of red blood cells hinders blood flow through the small capillaries and decreases oxygen absorption due to reduced surface area. Ozone reduces or eliminates clumping and red cell flexibility is restored, along with oxygen carrying ability. Oxygenation of the tissues increases as the arterial partial pressure increases and viscosity decreases. Ozone also oxidizes the plaque in arteries, allowing the removal of the breakdown products, unclogging the blood vessels.
3. Stimulation of oxygen metabolism:
Ozone causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2,3-diphosphoglycerate (2,3-DPG) which leads to an increase in the amount of oxygen released to the tissues. There is a stimulation of the production of the enzymes which act as free radical scavengers and cell wall protectors: glutathione peroxidase, catalase, and superoxide dismutase. Ozone activates the Krebs cycle by enhancing oxidative carboxylation of pyruvate, stimulating production of ATP. Ozone also causes a significant reduction in NADH and helps to oxidize cyochrome C. Prostacyline, a vasodilator, is also induced by ozone.
4. Formation of peroxides:
Ozone reacts with the unsaturated fatty acids of the lipid layer in cellular membranes, forming hydro peroxides. There is a synergistic effect with cellular- formed H2O2. Lipid peroxidation products include alkoxyl and peroxyl radicals, singlet oxygen, ozonides, carbonides, carbonyls, alkanes and alkenes.
5. Dissolution of malignant tumors:
Ozone inhibits tumor metabolism. In addition, ozone oxidizes the outer lipid layer of malignant cells and destroys them through cell lysis (break-down). Phagocytes produce H2O2 and hydroxyl to kill bacteria and viruses. The generation of hydroxyl by killer cells is critical to their cytotoxic capability. Ozone stimulates conversion of L- arginine to citrulline, nitrite and nitrate by phagocytes, acting on tumors.
The different modes of action of ozone on a living organism are now well understood and involve the production of peroxides. The peroxides are responsible for the remarkable bactericidal and fungicidal effects of ozone. The virus inactivation is enhanced by a peroxide intolerance of weakened infected cells. Normal cells are protected from the effects of ozone by enzymes in the cell wall - glutathione peroxidase, catalase and superoxide dismutase. Ozone stimulates the production of these enzymes, thus enhancing the cell wall resistance to invasion.
In addition, ozone has been shown to have a measurable benefit on the uptake and utilization of oxygen through improved glycolysis in red blood cells through the abolition of harmful red blood cell stacking. In addition, ozone stimulates and activates mitochondrial respiration and metabolic pathways.
Ozone and its uses in medical therapy
Ozone therapy is one of the most powerful and versatile therapies known today. Extensive medical research on ozone therapy has been done primarily in Europe. Through its mechanism of action, ozone has beneficial effects on every part of the body. The effects include:
1. Inactivation of bacteria, viruses and fungi: Ozone disrupts the intergrity of the cell envelope through peroxidation of the phospholipids and lipoproteins. In fungi, ozone inhibits cell growth at certain stages. With viruses, the ozone damages the viral capsid and disrupts the reproductive cycle by interrupting the virus-to-cell contact with peroxidation. Cells previously infected by viruses are more susceptible to destruction by the peroxide produced through ozonolysis, because they have weak enzyme coatings.
2. Enhancement of circulation: In circulatory disease, a clumping of red blood cells hinders blood flow and becreases oxygen absorption due to reduced surface area. There is a decrease in red blood cell flexibility which prevents them travelling down the tiniest capillaries, and blood viscosity increases. With ozone therapy, clumping is reduced or eliminated and flexibility is restored, along with oxygen carrying abiltiy. Oxygenation of the tissues increases as the arterial partial pressure increases, and viscosity decreases. Ozone also oxidizes the plaque in arteries allowing the removal of the breakdown products, unclogging vessels.
3. Stimulation of oxygen metabolism: Ozone causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2.3-diphosphoglycerate which shifts the oxyhemoglobin disassociation curve to the right. This leads to an increase in the amount of oxygen released to the surrounding tissues. There is a stimulation of the production of the enzymes which act as free radical scavengers and cell wall protectors: glutathione peroxidase, catalase and superoxide dismutase. Ozone activates the Krebs cycle by enhancing oxidative decarboxylation of pyruvate, stimulating production of ATP. Ozone also causes a significant reduction in HADH and helps oxidize cytochromes.
4. Dissolution of malignant tumors: Malignant cells have an increased rate of glycolysis which leads to the production of more lactate. With ozone therapy, there is a significant decrease in lactate production, showing that the metabolism is being inhibited Tumor cells have a peroxide intolerance due to insufficient peroxidase and catalase. Ozone is thus able to oxidize the outer lipid layer of malignant cells and destroy them through cell lysis.
5. Activation of the Immune system: Ozone stimulates the production of interferon and interleukin in the body. From this there is a cascade of subsequent immunological reactions.
6. Formation of peroxides: Ozone reacts with the unsaturated fatty acids of the lipid layer in celllular membranes, forming hydro peroxides. Lipid peroxidation products include peroxyl radicals, vital for killer cell action.
Oxygen plays a vital role in maintaining health in the body. Oxygen and sugar are the primary nutrients that each cell requires to generate energy for all its life functions. These functions include the transport of molecules, synthesis of all chemical compounds and mechanical work such as muscle contraction. Thousands of these reactions are occuring at all times. These reactions are what allow the heart to pump blood, the immune system to fight infection, the gastrointestinal tract to digest food, and the nervous system to process information.
Oxygen is also an important structural component of the organic compounds used by the body as essential nutrients, such as vitamins and fatty acids. Oxygen also has an important role in removing waste products from the system. As people age, their bodies extract oxygen and transport it to the cells less efficiently. The cumulative effect of this lack of oxygenation is a decrease in the flow of vital nutrients to the tissue, the impairment of the thousands of chemical reactions necessary and the subsequent appearance of deficiency diseases. Thus an abundance of oxygen creates health and well being and a deficiency of oxygen contributes to illness.
Properties of Medical Ozone
At the higher range of concentration (three and a half to five per cent ozone in a ozone/oxygen mixture) ozone exhibits a strong germicidal effect by oxidative destruction. The oxidative power of ozone has proven to be effective in destroying lipid-enveloped viruses such as Epstein-Barr, herpes, cytomegalovirus and viruses that cause hepatitis. One recent study indicates that ozone treatment was 97 to 100 per cent effective in destroying HIV in vitro (in a test tube). (Journal of American Society of Hematology, October 1, 1992) At concentrations below approximately three and a half per cent, the three main restitutional properties of ozone can be observed by its oxidative influence on the oxygen metabolism, the induction of specific enzymes and the activation of immunocompetent cells. It is these systemic influences of ozone that cause it to be such a potent therapeutic tool, because most of the diseases affecting humans today can be traced to diminishing levels of oxygen and a compromised immune system.
Ozone Improves Oxygen Metabolism
Ozone improves the delivery of oxygen to hypoxic tissues, as well as reactivating the oxygen metabolism of cells. The mechanisms of these systemic actions involve both direct and indirect processes.
Ozone directly changes the electric charges of the erythrocyte membrane increasing the flexibility and plasticity of the erythrocythes, thus enhancing the flow properties of the blood and the transport of oxygen to the cells and tissues. This is especially applicable in arterial occlusion disease whereby "pile of coins" erythrocyte formation is typical. The indirect mechanism consists of ozonolysis, ie. the ionizing reaction of ozone with the unsaturated fatty acids in the cellular membrane producing peroxides. It must be pointed out that ozone behaves as an ion, not a free radical under normal physiological blood pH and therfore no radical chain reaction occurs to cause oxidative damages. The reaction activates the enzyme 2,3-Diphosphoglycerate (2,3-DPG) in hemoglobin to release oxygen. This is of particular importance to diabetics in which 2,3-DPG is depressed.
Ozone Induces specific Enzymes The formation of short-lived peroxides at the membrane are injected into the cell and are removed by the enzyme glutathione peroxidase. Therefore, it is recommended to supplement with vitamin E, N-acetyl-cysteine and selenium during ozone therapy to support the glutathione detoxification system. In addition, the enhancement of the glycolysis enzymatic pathway results in an increase in adenosine triphosphate production (energy currency of the cell). This is significant in the management of stroke and burns. The elevation of adenosine triphosphate synthesis will decrease perifocal edema formed in the injured site minimizing tissue necrosis and subsequent scarring. But this is effective only when ozone is administered within the first 24 to 48 hours. In Germany, many ambulances are equipped with ozone and it is injected intravenously in patients who have just suffered stroke.
Ozone Acivates Immune System It is well documented that ozone can activate monocyte and lymphocytes, and induce the production of an array of cytokines such as interleukin, interferon, tumor-necrosis factor. (The Journal of International Medical Research 1994) Its ability to elicit endogenous production of cytokines and its lack of toxicity make ozone an indispensible therapeutic modality since today's most devastating diseases are characterized by immunodepression such as chronic viral diseases, cancer and AIDS. Of course, restoration of the immune system depends on a total approach of detoxification, lifestyle modification and supportive therapies. What does Ozone do?
inactivates viruses, bacteria, yeast fungi and protozoa stimulates the immune system supports and enhances the healing process cleans arteries and veins breaks up red blood cell clumping purifies the blood and the lymph normalises hormone and enzyme production reduces inflammation reduces pain, calms the nerves stops bleeding prevents shock scavenges free radicals prevents stroke damage reduces cardiac arrhythmia improves brain function and memory oxidises toxins, facilitating their excretion chelates heavy metals, working well with EDTA increases the partial pressure of oxygen in the blood stimulates production of all protective cell enzymes prevents and reverses degenerative diseases prevents and treats communicable diseases prevents and eliminates auto-immune diseases
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